I've been beta testing a new app for the Vive and Rift named ANIMVR. It's a drawing and painting program designed for frame by frame animation. It took a bit to get used to the controls, but I am seriously loving this!
The .gif in this post was sketched out tonight in about 1 hour of messing around in a "straight-ahead" approach. I definitely want to do more of this. Keep your eyes peeled for ANIMVR when it comes out.